Cagrilintide half-life & how long it lasts
Cagrilintide has a half-life of about 7.5 days (180 hours), reaches peak concentration around 24 hours after a dose, and is practically cleared from the body about 37.5 days (900 hours) after the last dose. Investigational. Roughly a 7 to 8 day half-life in published human PK work.
The numbers
| Half-life | 7.5 days (180 hours) |
|---|---|
| Time to peak | 24 hours |
| Route | injection |
| Typical cadence | once weekly (trial protocols) |
| Practically cleared | 37.5 days (900 hours) after the last dose (five half-lives, ~97% eliminated) |
| Steady state | after roughly 37.5 days (900 hours) of continuous once weekly (trial protocols) dosing |
| Evidence | FDA label or published human PK |
What that means day to day
- Levels are never zero between doses. On a once weekly (trial protocols) schedule with a 7.5 days (180 hours) half-life, each dose stacks on what is left of the last one until steady state.
- Peak is not injection day. Concentration keeps climbing for about 24 hours after the shot, so effects and side effects lag the dose.
- Stopping is gradual. After the last dose it takes about 37.5 days (900 hours) for the compound to be practically gone.
Sources
Track it instead of estimating it
Bo models this curve from your own logged doses, so you can see what is still in your system right now instead of doing the arithmetic. It also handles reconstitution math, dose reminders and injection-site rotation.
Compare every compound in one table →
Educational information only. Bo is a tracking app, not a medical device, and nothing here is medical advice, a dosing recommendation, or a substitute for your prescriber. Half-lives are population averages from the sources cited on each row; individual clearance varies with body weight, kidney and liver function, and other medication.