GLP-1 & peptide half-life chart

By Melvin Morina · Updated 2026-07-27

The chart

How to read it

A half-life is the time it takes for half of what is in your body to be eliminated. It compounds: after one half-life about 50% remains, after two about 25%, after five about 3%. That five half-life mark is the convention behind the "practically cleared" column, and it is also roughly when levels stop climbing on a repeating schedule, which is why steady state on weekly semaglutide takes 4 to 5 weeks.

Time to peak is the other half of the picture. Semaglutide peaks 1 to 3 days after the injection, not within hours, so side effects that show up two days later are not a coincidence.

Sources

• Tirzepatide — Mounjaro FDA label, Zepbound FDA label, Mounjaro FDA multidiscipline review
• Semaglutide (injectable) — Ozempic FDA label, Wegovy FDA label, Ozempic FDA multidiscipline review
• Semaglutide (oral) — Rybelsus FDA label, Oral semaglutide PK study
• Liraglutide — Victoza FDA label, Saxenda FDA label
• Dulaglutide — Trulicity FDA label
• Exenatide (immediate release) — Byetta FDA label
• Retatrutide — NEJM phase 2 obesity trial
• Survodutide — NEJM survodutide trial
• Cagrilintide — Cagrilintide human PK study
• Orforglipron — FDA Drugs@FDA record
• Tesamorelin — Egrifta FDA label
• PT-141 (Bremelanotide) — Vyleesi FDA label
• MK-677 (Ibutamoren) — Ibutamoren clinical pharmacokinetics
• CJC-1295 (with DAC) — CJC-1295 human PK study
• Ipamorelin — Ipamorelin research
• BPC-157 — BPC-157 research
• TB-500 (Thymosin β4) — Thymosin β4 research
• Sermorelin — Sermorelin PK research
• GHK-Cu — GHK-Cu research
• MOTS-c — MOTS-c research
• NAD+ — NAD+ metabolism research
• Epitalon — Epitalon research
• GHRP-2 — GHRP-2 PK research
• GHRP-6 — GHRP-6 research
• Hexarelin — Hexarelin research
• HGH Fragment 176-191 — HGH 176-191 research
• Thymosin Alpha-1 — Thymalfasin research
• KPV — KPV peptide research
• SS-31 (Elamipretide) — Elamipretide PK research
• Semax — Semax research
• Selank — Selank research
• DSIP — DSIP research
• AOD-9604 — AOD-9604 research
• Tesofensine — Tesofensine PK study
• 5-Amino-1MQ — 5-Amino-1MQ research
• Kisspeptin — Kisspeptin research
• Oxytocin — Oxytocin PK research
• Melanotan II — Melanotan II research

What this does not tell you

• These are population averages. Kidney function, liver function, body weight and other medication all shift real clearance.
• Rows tagged limited data are not backed by an FDA label or a full human PK study. They are the best published estimate and should be read as directional.
• Half-life describes the drug in your blood, not how long you feel it. Appetite suppression and side effects follow their own curves.
• This chart cannot tell you what to do about a missed or late dose. That belongs with your prescriber, and the labels linked above are the authority.

Educational information only. Bo is a tracking app, not a medical device, and nothing here is medical advice, a dosing recommendation, or a substitute for your prescriber. Half-lives are population averages from the sources cited on each row; individual clearance varies with body weight, kidney and liver function, and other medication.