NAD+ half-life & how long it lasts
NAD+ has a half-life of about 2 hours, reaches peak concentration around 30 minutes after a dose, and is practically cleared from the body about 10 hours after the last dose. NAD+ is metabolised rapidly and its kinetics vary with route; the figure is an approximation.
The numbers
| Half-life | 2 hours |
|---|---|
| Time to peak | 30 minutes |
| Route | injection |
| Typical cadence | protocols vary |
| Practically cleared | 10 hours after the last dose (five half-lives, ~97% eliminated) |
| Steady state | after roughly 10 hours of continuous protocols vary dosing |
| Evidence | limited human data — directional only |
What that means day to day
- Levels are never zero between doses. On a protocols vary schedule with a 2 hours half-life, each dose stacks on what is left of the last one until steady state.
- Peak is not injection day. Concentration keeps climbing for about 30 minutes after the shot, so effects and side effects lag the dose.
- Stopping is gradual. After the last dose it takes about 10 hours for the compound to be practically gone.
- Read this one loosely. There is no FDA label or full human pharmacokinetic study behind this figure.
Sources
Track it instead of estimating it
Bo models this curve from your own logged doses, so you can see what is still in your system right now instead of doing the arithmetic. It also handles reconstitution math, dose reminders and injection-site rotation.
Compare every compound in one table →
Educational information only. Bo is a tracking app, not a medical device, and nothing here is medical advice, a dosing recommendation, or a substitute for your prescriber. Half-lives are population averages from the sources cited on each row; individual clearance varies with body weight, kidney and liver function, and other medication.